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Latest news Chronic pain and the power of placebo. Leptin's ability to regulate bone mass was first recognized in Leptin was approved in the United States in for use in congenital leptin deficiency and generalized lipodystrophy. Hyperleptinemia produced by infusion or adenoviral gene transfer decreases blood pressure in rats. Once leptin has bound to the Ob-Rb receptor, it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in gene expression, one of the main effects being the down-regulation of the expression of endocannabinoids , responsible for increasing hunger. Although regulation of fat stores is deemed to be the primary function of leptin, it also plays a role in other physiological processes, as evidenced by its many sites of synthesis other than fat cells, and the many cell types beside hypothalamic cells that have leptin receptors.
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